Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review

Caroline Moura Martins Lobo Santos, Ronaldo Lira-Junior, Ricardo Guimarães Fischer, Ana Paula Pires Santos and Branca Heloisa Oliveira

PLOS ONE, 2015, vol. 10, issue 12, 1-11

Abstract: Aim: To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients. Materials and Methods: Two independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searches yielded 1,878 records; 18 full-text articles were independently read by two reviewers. To evaluate the additional effect of antibiotic usage, pooled weighted mean differences and 95% confidence intervals were calculated using a fixed effects model. Results: Five studies met the inclusion criteria, four of which were included in meta-analyses. The meta-analyses showed a significant effect favouring SRP plus antibiotic for reductions in mean probing depth (PD) (-0.22 mm [-0.34, -0.11]) and mean percentage of bleeding on probing (BoP) (4% [-7, -1]). There was no significant effect for clinical attachment level gain and plaque index reduction. No study reported on tooth loss and oral health-related quality of life. Conclusion: Adjunctive systemic antibiotic use in diabetic patients provides a small additional benefit in terms of reductions in mean PD and mean percentage of BoP. Registration: PROSPERO: CRD42013006389.

Date: 2015
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0145262

DOI: 10.1371/journal.pone.0145262

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