Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans

Yolanda Saldaña-Alvarez, María Guadalupe Salas-Martínez, Humberto García-Ortiz, Angélica Luckie-Duque, Gustavo García-Cárdenas, Hermenegildo Vicenteño-Ayala, Emilio J Cordova, Marcelino Esparza-Aguilar, Cecilia Contreras-Cubas, Alessandra Carnevale, Margarita Chávez-Saldaña and Lorena Orozco

PLOS ONE, 2016, vol. 11, issue 1, 1-12

Abstract: To evaluate the associations between six single-nucleotide polymorphisms (SNPs) in intron 1 of FTO and body mass index (BMI), a case-control association study of 2314 unrelated Mexican-Mestizo adult subjects was performed. The association between each SNP and BMI was tested using logistic and linear regression adjusted for age, gender, and ancestry and assuming additive, recessive, and dominant effects of the minor allele. Association analysis after BMI stratification showed that all five FTO SNPs (rs1121980, rs17817449, rs3751812, rs9930506, and rs17817449), were significantly associated with obesity class II/III under an additive model (P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0145984

DOI: 10.1371/journal.pone.0145984

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