Intravoxel Incoherent Motion MR Imaging for Staging of Hepatic Fibrosis

Bin Zhang, Long Liang, Yuhao Dong, Zhouyang Lian, Wenbo Chen, Changhong Liang and Shuixing Zhang

PLOS ONE, 2016, vol. 11, issue 1, 1-13

Abstract: Objectives: To determine the potential of intravoxel incoherent motion (IVIM) MR imaging for staging of hepatic fibrosis (HF). Methods: We searched PubMed and EMBASE from their inception to 31 July 2015 to select studies reporting IVIM MR imaging and HF staging. We defined F1-2 as non-advanced HF, F3-4 as advanced HF, F0 as normal liver, F1 as very early HF, and F2-4 as significant HF. Then we compared stage F0 with F1, F0-1 with F2-3, and F1-2 with F3-4 using IVIM-derived parameters (pseudo-diffusion coefficient D*, perfusion fraction f, and pure molecular diffusion parameter D). The effect estimate was expressed as a pooled weighted mean difference (WMD) with 95% confidence interval (CI), using the fixed-effects model. Results: Overall, we included six papers (406 patients) in this study. Significant differences in D* were observed between F0 and F1, F0-1 and F2-3, and F1-2 and F3-4 (WMD 2.46, 95% CI 0.83–4.09, P = 0.006; WMD 13.10, 95% CI 9.53–16.67, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0147789

DOI: 10.1371/journal.pone.0147789

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