Association between Tooth Loss and Gastric Cancer: A Meta-Analysis of Observational Studies

Xin-Hai Yin, Ya-Dong Wang, Hong Luo, Ke Zhao, Guang-Lei Huang, Si-Yang Luo, Ju-Xiang Peng and Ju-Kun Song

PLOS ONE, 2016, vol. 11, issue 3, 1-13

Abstract: Observational studies showed that tooth loss is associated with gastric cancer, but the findings are inconsistent. In this study, a meta-analysis was conducted to evaluate the relationship between tooth loss and gastric cancer. Relevant studies were screened in PubMed and Embase databases, and nine observational studies were considered eligible for the analysis. The combined relative risks for the highest versus the lowest categories of tooth loss were 1.86 (95% CI: 1.08–3.21) and 1.31 (95% CI: 1.12–1.53) in case control and cohort studies, respectively. However, unstable results were observed in the stratified and sensitivity analysis. The current evidence, based solely on four case-control studies and five cohort studies, suggested that tooth loss is a potential marker of gastric cancer. However, we can not concluded at this time that tooth loss may be a risk factor for gastric cancer due to significant heterogeneity among studies and mixed results between case-control studies and cohort studies. Additional large-scale and high-quality prospective studies are required to evaluate the association between tooth loss and risk of gastric cancer.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0149653

DOI: 10.1371/journal.pone.0149653

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