Morphological and Hemodynamic Discriminators for Rupture Status in Posterior Communicating Artery Aneurysms

Nan Lv, Chi Wang, Christof Karmonik, Yibin Fang, Jinyu Xu, Ying Yu, Wei Cao, Jianmin Liu and Qinghai Huang

PLOS ONE, 2016, vol. 11, issue 2, 1-9

Abstract: Background and Purpose: The conflicting findings of previous morphological and hemodynamic studies on intracranial aneurysm rupture may be caused by the relatively small sample sizes and the variation in location of the patient-specific aneurysm models. We aimed to determine the discriminators for aneurysm rupture status by focusing on only posterior communicating artery (PCoA) aneurysms. Materials and Methods: In 129 PCoA aneurysms (85 ruptured, 44 unruptured), clinical, morphological and hemodynamic characteristics were compared between the ruptured and unruptured cases. Multivariate logistic regression analysis was performed to determine the discriminators for rupture status of PCoA aneurysms. Results: While univariate analyses showed that the size of aneurysm dome, aspect ratio (AR), size ratio (SR), dome-to-neck ratio (DN), inflow angle (IA), normalized wall shear stress (NWSS) and percentage of low wall shear stress area (LSA) were significantly associated with PCoA aneurysm rupture status. With multivariate analyses, significance was only retained for higher IA (OR = 1.539, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0149906

DOI: 10.1371/journal.pone.0149906

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