Excess Mortality Attributable to Clostridium difficile and Risk Factors for Infection in an Historic Cohort of Hospitalised Patients Followed Up in the United Kingdom Death Register

Mark Reacher, Neville Q Verlander, Iain Roddick, Cheryl Trundle, Nicholas Brown, Mark Farrington and Philip Jones

PLOS ONE, 2016, vol. 11, issue 3, 1-23

Abstract: Methods: We compared time from hospital admission to death in a probability sample of 100 Clostridium difficile infected cases and a probability sample of 98 non-cases admitted to an English teaching hospital between 2005 and 2007 with follow up in the UK national death register using survival analysis. Results: Clostridium difficile infection was associated with a 50% increased risk of death (Hazard Ratio 1.51 (95% CI: 1.05–2.19 p = 0.03) at between five to eight years in Cox Regression analysis adjusting for age, sex, Charlson comorbidity index, diagnosis of a malignant condition and insertion of a nasogastric tube during admission. Acquisition of Clostridium difficile infection was independently associated with an almost six fold higher odds of being admitted with a diagnosis of infection of any other type (OR 5.79 (2.19, 15.25) p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0149983

DOI: 10.1371/journal.pone.0149983

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