Central Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model

Francesco Tosello, Andrea Guala, Dario Leone, Carlo Camporeale, Giulia Bruno, Luca Ridolfi, Franco Veglio and Alberto Milan

PLOS ONE, 2016, vol. 11, issue 3, 1-10

Abstract: Introduction: Current evidence suggests that aortic blood pressure has a superior prognostic value with respect to brachial pressure for cardiovascular events, but direct measurement is not feasible in daily clinical practice. Aim: The aim of the present study is the clinical validation of a multiscale mathematical model for non-invasive appraisal of central blood pressure from subject-specific characteristics. Methods: A total of 51 young male were selected for the present study. Aortic systolic and diastolic pressure were estimated with a mathematical model and were compared to the most-used non-invasive validated technique (SphygmoCor device, AtCor Medical, Australia). SphygmoCor was calibrated through diastolic and systolic brachial pressure obtained with a sphygmomanometer, while model inputs consist of brachial pressure, height, weight, age, left-ventricular end-systolic and end-diastolic volumes, and data from a pulse wave velocity study. Results: Model-estimated systolic and diastolic central blood pressures resulted to be significantly related to SphygmoCor-assessed central systolic (r = 0.65 p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0151523

DOI: 10.1371/journal.pone.0151523

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