Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis

Zhangjian Zhou, Hao Zhang, Jianguo Lai, Dongmei Diao, Wenhan Li, Chengxue Dang and Yongchun Song

PLOS ONE, 2016, vol. 11, issue 3, 1-12

Abstract: We conducted a meta-analysis to explore the relationships between p14ARF gene methylation and clinicopathological features of colorectal cancer (CRC). Databases, including Pubmed, Embase and Cochrane Library, were searched and, finally, a total of 18 eligible researches encompassing 1988 CRC patients were selected. Combined odds ratios (ORs) with 95% confidence intervals (95% CIs) were evaluated under a fixed effects model for absence of heterogeneity. Significant associations were observed between p14ARF gene methylation and tumor location (OR = 2.35, 95% CI: 1.55–3.55, P = 0.001), microsatellite instability (MSI) status (OR = 3.28, 95% CI: 2.12–5.07, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0152050

DOI: 10.1371/journal.pone.0152050

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