Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2

Takanobu Nagata, Hiroshi Sobajima, Norimi Ohashi, Akihiro Hirakawa, Takayuki Katsuno, Yoshinari Yasuda, Seiichi Matsuo, Naotake Tsuboi and Shoichi Maruyama

PLOS ONE, 2016, vol. 11, issue 5, 1-11

Abstract: Background: Data regarding the association between 24h urinary sodium and potassium excretion with kidney outcomes in patients with diabetes mellitus is currently scarce. Methods: We conducted a single-center, retrospective cohort study in which 1230 patients with diabetes who had undergone a 24h urinary sodium and potassium excretion test were analyzed. Patients with incomplete urine collection were excluded based on 24h urinary creatinine excretion. Outcomes were the composite of a 30% decline in eGFR or death. Multivariate cox regression analysis was used to investigate the association between urinary sodium and potassium excretion and outcomes. Results: With a mean follow up period of 5.47 years, 130 patients reached the outcomes (30% decline in eGFR: 124, death: 6). Mean (SD) eGFR and 24h urinary sodium and potassium excretion at baseline were 78.6 (19.5) ml/min/1.73m2, 4.50 (1.64) g/day, and 2.14 (0.77) g/day. Compared with sodium excretion

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0152306

DOI: 10.1371/journal.pone.0152306

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