Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain Natriuretic Peptide and Calcidiol Are Independently Associated with the Complexity of Coronary Artery Disease

Roberto Martín-Reyes, Juan Antonio Franco-Peláez, Óscar Lorenzo, María Luisa González-Casaus, Ana María Pello, Álvaro Aceña, Rocío Carda, José Luis Martín-Ventura, Luis Blanco-Colio, María Luisa Martín-Mariscal, Juan Martínez-Milla, Ricardo Villa-Bellosta, Antonio Piñero, Felipe Navarro, Jesús Egido and José Tuñón

PLOS ONE, 2016, vol. 11, issue 5, 1-14

Abstract: Background and Objectives: We investigated the relationship of the Syntax Score (SS) and coronary artery calcification (CAC), with plasma levels of biomarkers related to cardiovascular damage and mineral metabolism, as there is sparse information in this field. Methods: We studied 270 patients with coronary disease that had an acute coronary syndrome (ACS) six months before. Calcidiol, fibroblast growth factor-23, parathormone, phosphate and monocyte chemoattractant protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3, and N-terminal pro-brain natriuretic peptide [NT-proBNP] levels, among other biomarkers, were determined. CAC was assessed by coronary angiogram as low-grade (0–1) and high-grade (2–3) calcification, measured with a semiquantitative scale ranging from 0 (none) to 3 (severe). For the SS study patients were divided in SS

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0152816

DOI: 10.1371/journal.pone.0152816

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