Clinical Factors Associated with Lamina Cribrosa Thickness in Patients with Glaucoma, as Measured with Swept Source Optical Coherence Tomography

Kazuko Omodaka, Seri Takahashi, Akiko Matsumoto, Shigeto Maekawa, Tsutomu Kikawa, Noriko Himori, Hidetoshi Takahashi, Kazuichi Maruyama, Hiroshi Kunikata, Masahiro Akiba and Toru Nakazawa

PLOS ONE, 2016, vol. 11, issue 4, 1-18

Abstract: Purpose: To investigate the influence of various risk factors on thinning of the lamina cribrosa (LC), as measured with swept-source optical coherence tomography (SS-OCT; Topcon). Methods: This retrospective study comprised 150 eyes of 150 patients: 22 normal subjects, 28 preperimetric glaucoma (PPG) patients, and 100 open-angle glaucoma patients. Average LC thickness was determined in a 3 x 3 mm cube scan of the optic disc, over which a 4 x 4 grid of 16 points was superimposed (interpoint distance: 175 μm), centered on the circular Bruch’s membrane opening. The borders of the LC were defined as the visible limits of the LC pores. The correlation of LC thickness with Humphrey field analyzer-measured mean deviation (MD; SITA standard 24–2), circumpapillary retinal nerve fiber layer thickness (cpRNFLT), the vertical cup-to-disc (C/D) ratio, and tissue mean blur rate (MBR) was determined with Spearman's rank correlation coefficient. The relationship of LC thickness with age, axial length, intraocular pressure (IOP), MD, the vertical C/D ratio, central corneal thickness (CCT), and tissue MBR was determined with multiple regression analysis. Average LC thickness and the correlation between LC thickness and MD were compared in patients with the glaucomatous enlargement (GE) optic disc type and those with non-GE disc types, as classified with Nicolela’s method. Results: We found that average LC thickness in the 16 grid points was significantly associated with overall LC thickness (r = 0.77, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0153707

DOI: 10.1371/journal.pone.0153707

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