Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in China

Bingsheng Lou, Lixia Lin, Junlian Tan, Yao Yang, Zhaohui Yuan and Xiaofeng Lin

PLOS ONE, 2016, vol. 11, issue 6, 1-11

Abstract: Purpose: To elucidate the Chinese practice of intraocular antibiotics administration for prophylaxis after open globe injury. Methods: A cross-sectional questionnaire survey was performed online by scanning a Quickmark (QR) code with smartphones at the 20th Chinese National Conference of Ocular Trauma in November 2014. Results: A total of 153 (30.6%) of all participators at the conference responded. Of the respondents, 20.9% were routinely administered with prophylactic intraocular injection of antibiotics at the conclusion of the primary eye repair, and 56.9% were used only in cases with high risk of endophthalmitis development. The intraocular route of delivery was mainly included with intracameral injection (47.9%) and intravitreal injection (42.0%). Cephalosporins (53.8%) and vancomycin (42.0%) were the main choices of antibiotic agents, followed by fluoroquinolones (24.3%), and aminoglycosides (13.4%). Only 21.9% preferred a combination of two or more two drugs routinely. In addition, significantly more respondents from the referral eye hospital (92.7%) replied using intraocular antibiotics injection for prophylaxis compared to those respondents from the primary hospital (69.4%) (p = 0.001, Fisher’s exact test). Conclusions: Intraocular antibiotics injection for post-traumatic endophthalmitis prophylaxis is widely used in China. However, the choice of antibiotic agents and the intraocular route of delivery vary. A well-designed clinical trial is needed to establish a standardized protocol of intraocular antibiotics administration for post-traumatic endophthalmitis prophylaxis.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0156856

DOI: 10.1371/journal.pone.0156856

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