Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis

Yanqiang Shi, Yiwei Dong, Wenhui Huang, Decong Zhu, Hua Mao and Peizhu Su

PLOS ONE, 2016, vol. 11, issue 6, 1-18

Abstract: Background: Fecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear. Objective: We conducted this systematic review to assess the efficacy and safety of FMT in UC. Data Sources: PubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for reports of FMT in UC with clear outcomes. Data Extraction and Synthesis: We estimated pooled rates [with 95% confidence interval (CI)] of clinical remission among 15 cohort studies and clinical response among 16 cohort studies. Results: Twenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall, 41.58% (84/202) patients achieved clinical remission (CR) and 65.28% (126/193) achieved clinical response. Among the cohort studies, the pooled estimate of patients who achieved CR and clinical response were 40.5% (95% CI 24.7%-58.7%), and 66.1% (95% CI 43.7%-83.0%). Most adverse events were slight and self-resolving. The analyses of gut microbiota in 7 studies showed that FMT could increase microbiota diversity and richness, similarity, and certain change of bacterial composition. Conclusion: FMT provides a promising effect for UC with few adverse events. Successful FMT may be associated with an increase in microbiota diversity and richness, similarity, and certain change of bacterial composition.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0157259

DOI: 10.1371/journal.pone.0157259

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