Cervical Cancer Genetic Susceptibility: A Systematic Review and Meta-Analyses of Recent Evidence

Gabriela A Martínez-Nava, Julián A Fernández-Niño, Vicente Madrid-Marina and Kirvis Torres-Poveda

PLOS ONE, 2016, vol. 11, issue 7, 1-23

Abstract: Introduction: Cervical cancer (CC) has one of the highest mortality rates among women worldwide. Several efforts have been made to identify the genetic susceptibility factors underlying CC development. However, only a few polymorphisms have shown consistency among studies. Materials and Methods: We conducted a systematic review of all recent case-control studies focused on the evaluation of single nucleotide polymorphisms (SNPs) and CC risk, stringently following the “PRISMA” statement recommendations. The MEDLINE data base was used for the search. A total of 100 case-control studies were included in the meta-analysis. Polymorphisms that had more than two reports were meta-analyzed by fixed or random models according to the heterogeneity presented among studies. Results: We found significant negative association between the dominant inheritance model of p21 rs1801270 polymorphism (C/A+A/A) and CC (pooled OR = 0.76; 95%CI: 0.63–0.91; p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0157344

DOI: 10.1371/journal.pone.0157344

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