Possible Predictors of Involuntary Weight Loss in Patients with Alzheimer’s Disease

Massimo Venturelli, Emiliano Cè, Eloisa Limonta, Ettore Muti, Renato Scarsini, Anna Brasioli, Federico Schena and Fabio Esposito

PLOS ONE, 2016, vol. 11, issue 6, 1-18

Abstract: Loss in body mass (∆BM) is a common feature in patients with Alzheimer’s disease (AD). However, the etiology of this phenomenon is unclear. The aim of this cohort study was to observe possible ∆BM in AD patients following a standard institutionalized diet. Secondary objective was to identify possible predictors of ∆BM. To this end, 85 AD patients (age: 76±4 yrs; stature: 165±3 cm; BM: 61.6±7.4 kg; mean±standard deviation) and 86 controls (CTRL; age: 78±5 yrs; stature: 166±4 cm; BM: 61.7±6.4 kg) were followed during one year of standard institutionalized diet (~1800 kcal/24h). BM, daily energy expenditure, albuminemia, number of medications taken, and cortisolism, were recorded PRE and POST the observation period. Potential predictors of ∆BM in women (W) and men (M) with AD were calculated with a forward stepwise regression model. After one year of standard institutionalized diet, BM decreased significantly in AD (-2.5 kg; p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0157384

DOI: 10.1371/journal.pone.0157384

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