Serum Soluble (Pro)Renin Receptor Levels in Maintenance Hemodialysis Patients

Yoshifumi Amari, Satoshi Morimoto, Fumitaka Nakajima, Takashi Ando and Atsuhiro Ichihara

PLOS ONE, 2016, vol. 11, issue 7, 1-13

Abstract: The (pro)renin receptor [(P)RR] is cleaved by furin to generate soluble (P)RR [s(P)RR], which reflects the status of the tissue renin-angiotensin system. Hemodialysis patients have advanced atherosclerosis. The aim of this study was to investigate the relationships between serum s(P)RR levels and background factors, including indices of atherosclerosis, in hemodialysis patients. Serum s(P)RR levels were measured in hemodialysis patients and clearance of s(P)RR through the membrane of the dialyzer was examined. Furthermore, relationships between serum s(P)RR levels and background factors were assessed. Serum s(P)RR levels were significantly higher in hemodialysis patients (30.4 ± 6.1 ng/ml, n = 258) than those in subjects with normal renal function (21.4 ± 6.2 ng/ml, n = 39, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0158068

DOI: 10.1371/journal.pone.0158068

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