Retinal Vessel Analysis (RVA) in the Context of Subarachnoid Hemorrhage - A Proof of Concept Study

Walid Albanna, Catharina Conzen, Miriam Weiss, Hans Clusmann, Matthias Fuest, Marguerite Mueller, Marc Alexander Brockmann, Walthard Vilser, Arno Schmidt-Trucksäss, Anke Hoellig, Marcel Seiz, Claudius Thomé, Konstantin Kotliar and Gerrit Alexander Schubert

PLOS ONE, 2016, vol. 11, issue 7, 1-13

Abstract: Background: Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods: In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results: Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0158781

DOI: 10.1371/journal.pone.0158781

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