Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer’s Disease Risk: A Meta-Analysis

Hai Yuan, Qing Xia, Kang Ling, Xiaotong Wang, Xiumin Wang and Xunping Du

PLOS ONE, 2016, vol. 11, issue 7, 1-14

Abstract: Background: Epidemiological studies have investigated the role of choline acetyltransferase (ChAT) in Alzheimer’s disease (AD). ChAT gene polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A, and rs3810950G/A) may be associated with the risk of AD. In this meta-analysis, we determined the relationship between the four polymorphisms and the risk of AD. Methods: We searched MEDLINE, EMBASE, and HuGEnet databases for studies linking the four polymorphisms with AD risk. We included 16 articles in our meta-analysis to assess the association between the four polymorphisms and susceptibility to AD by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: The combined results showed no significant association with rs1880676G/A and rs2177369G/A polymorphisms. The risk of AD (GG+GA versus AA: OR = 0.01, 95%CI = 0.01–0.02, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0159022

DOI: 10.1371/journal.pone.0159022

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