AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials

Graham M Wheeler, Michael J Sweeting and Adrian Mander ()

PLOS ONE, 2016, vol. 11, issue 7, 1-17

Abstract: In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0159026

DOI: 10.1371/journal.pone.0159026

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