Diffusion Tensor MR Imaging Evaluation of Callosal Abnormalities in Schizophrenia: A Meta-Analysis

Chuanjun Zhuo, Mei Liu, Lina Wang, Hongjun Tian and Jinsong Tang

PLOS ONE, 2016, vol. 11, issue 8, 1-12

Abstract: Widespread white matter (WM) abnormalities have been found in patients with schizophrenia. Corpus callosum (CC) is the key area that connects the left and right brain hemispheres. However, the results of studies considering different subregions of the CC as regions of interest in patients with schizophrenia have been inconsistent. To obtain a more consistent evaluation of the diffusion characteristics change of the corpus callosum (CC) related to schizophrenia. A meta-analysis involving fractional anisotropy (FA) values in the CC of 729 schizophrenic subjects and 682 healthy controls from 22 studies was conducted. Overall FA values in the CC of the schizophrenic group were less than that of the healthy control group [weighted mean difference (WMD) = -0.021,P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0161406

DOI: 10.1371/journal.pone.0161406

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