Weight Change Is a Characteristic Non-Motor Symptom in Drug-Naïve Parkinson’s Disease Patients with Non-Tremor Dominant Subtype: A Nation-Wide Observational Study

Jun Kyu Mun, Jinyoung Youn, Jin Whan Cho, Eung-Seok Oh, Ji Sun Kim, Suyeon Park, Wooyoung Jang, Jin Se Park, Seong-Beom Koh, Jae Hyeok Lee, Hee Kyung Park, Han-Joon Kim, Beom S Jeon, Hae-Won Shin, Sun-Ah Choi, Sang Jin Kim, Seong-Min Choi, Ji-Yun Park, Ji Young Kim, Sun Ju Chung, Chong Sik Lee, Tae-Beom Ahn, Won Chan Kim, Hyun Sook Kim, Sang Myung Cheon, Jae Woo Kim, Hee-Tae Kim, Jee-Young Lee, Ji Sun Kim, Eun-Joo Kim, Jong-Min Kim, Kwang Soo Lee, Joong-Seok Kim, Min-Jeong Kim, Jong Sam Baik, Ki-Jong Park, Hee Jin Kim, Mee Young Park, Ji Hoon Kang, Sook Kun Song, Yong Duk Kim, Ji Young Yun, Ho-Won Lee, In-Uk Song, Young H Sohn, Phil Hyu Lee, Jeong-Ho Park, Hyung Geun Oh, Kun Woo Park and Do-Young Kwon

PLOS ONE, 2016, vol. 11, issue 9, 1-9

Abstract: Despite the clinical impact of non-motor symptoms (NMS) in Parkinson’s disease (PD), the characteristic NMS in relation to the motor subtypes of PD is not well elucidated. In this study, we enrolled drug-naïve PD patients and compared NMS between PD subtypes. We enrolled 136 drug-naïve, early PD patients and 50 normal controls. All the enrolled PD patients were divided into tremor dominant (TD) and non-tremor dominant (NTD) subtypes. The Non-Motor Symptom Scale and scales for each NMS were completed. We compared NMS and the relationship of NMS with quality of life between normal controls and PD patients, and between the PD subtypes. Comparing with normal controls, PD patients complained of more NMS, especially mood/cognitive symptoms, gastrointestinal symptoms, unexplained pain, weight change, and change in taste or smell. Between the PD subtypes, the NTD subtype showed higher total NMS scale score and sub-score about weight change. Weight change was the characteristic NMS related to NTD subtype even after controlled other variables with logistic regression analysis. Even from the early stage, PD patients suffer from various NMS regardless of dopaminergic medication. Among the various NMS, weight change is the characteristic NMS associated with NTD subtype in PD patients.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0162254

DOI: 10.1371/journal.pone.0162254

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