Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study

Simon Endes, Seraina Caviezel, Emmanuel Schaffner, Julia Dratva, Christian Schindler, Nino Künzli, Martin Bachler, Siegfried Wassertheurer, Nicole Probst-Hensch and Arno Schmidt-Trucksäss

PLOS ONE, 2016, vol. 11, issue 9, 1-12

Abstract: Background and Objectives: There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional vascular biomarkers in a population-based Caucasian cohort. We examined these associations in the second follow-up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3). Methods: Arterial stiffness was measured oscillometrically by pulse wave analysis to derive the cardio-ankle vascular index (CAVI), brachial-ankle (baPWV) and aortic pulse wave velocity (aPWV), and amplitude of the forward and backward wave. Carotid ultrasonography was used to measure carotid intima-media thickness (cIMT) and carotid lumen diameter (LD), and to derive a distensibility coefficient (DC). We used multivariable linear regression models adjusted for several potential confounders for 2,733 people aged 50–81 years. Results: CAVI, aPWV and the amplitude of the forward and backward wave were significant predictors of cIMT (p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0163844

DOI: 10.1371/journal.pone.0163844

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