Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results

Pawel Kuklik, Benjamin Schäffer, Boris A Hoffmann, Anand N Ganesan, Doreen Schreiber, Julia M Moser, Ruken Ö Akbulak, Arian Sultan, Daniel Steven, Bart Maesen, Ulrich Schotten, Christian Meyer and Stephan Willems

PLOS ONE, 2016, vol. 11, issue 10, 1-15

Abstract: Background: Electrogram-based identification of the regions maintaining persistent Atrial Fibrillation (AF) is a subject of ongoing debate. Here, we explore the concept of local electrical dyssynchrony to identify AF drivers. Methods and Results: Local electrical dyssynchrony was calculated using mean phase coherence. High-density epicardial mapping along with mathematical model were used to explore the link between local dyssynchrony and properties of wave conduction. High-density mapping showed a positive correlation between the dyssynchrony and number of fibrillatory waves (R2 = 0.68, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0164236

DOI: 10.1371/journal.pone.0164236

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