Prognostic Value of Serum Lactate Dehydrogenase in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Jie Shen, Zhen Chen, Qianfeng Zhuang, Min Fan, Tao Ding, Hao Lu and Xiaozhou He

PLOS ONE, 2016, vol. 11, issue 11, 1-13

Abstract: Background: Recently, many studies have shown that the serum lactate dehydrogenase (LDH) level is related to the prognosis of renal cell carcinoma (RCC). We launched this meta-analysis to assess the prognostic value of serum LDH in patients with RCC. Methods: We searched PubMed, Embase and Web of Science for information on serum LDH and the outcome of RCC through June 14, 2016. The hazard ratio (HR) and its 95% confidence interval (CI) for overall survival (OS) and progression-free survival (PFS) were extracted and integrated from the matching studies. Results: A total of 29 studies including 6629 patients with RCC were incorporated in this meta-analysis. Patients whose serum LDH levels were elevated had a lower OS (HR = 2.13, 95% CI = 1.69–2.69, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0166482

DOI: 10.1371/journal.pone.0166482

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