Aberrant IgA1 Glycosylation in IgA Nephropathy: A Systematic Review

Qiang Sun, Zhenhai Zhang, Hong Zhang and Xiaorong Liu

PLOS ONE, 2016, vol. 11, issue 11, 1-15

Abstract: Objective: Galactose-deficient IgA1 was evaluated in patients with IgA nephropathy(IgAN) and controls in order to determine the predictive value of galactose-deficient IgA1 in cases of IgA nephropathy. Methods: PubMed, EMBASE, Cochrane central register of controlled trials, CNKI, CBM disc, and VIP database were searched to identify eligible studies that evaluated a difference in aberrant IgA1 glycosylation in IgAN patients compared with controls. A meta-analysis was conducted to evaluate the impact of galactose-deficient IgA1(Gd-IgA1) levels in different groups. Results: A total of 22 studies (n = 1657) met inclusion criteria. The mean Newcastle-Ottawa Scale (NOS) score was 7.2 and ranged from 6 to 8. The standard mean difference(SMD) in the meta-analysis of 20 studies of the level of Gd-IgA1 in the serum and/or supernatant of cultured cells was higher in the IgAN group compared with healthy controls as well as in those with other renal diseases (SMD = 1.76, 95% CI = 1.18–2.34, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0166700

DOI: 10.1371/journal.pone.0166700

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