Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity

Ming-Ling Chang, Chia-Jung Kuo, Hsin-Chih Huang, Yin-Yi Chu and Cheng-Tang Chiu

PLOS ONE, 2016, vol. 11, issue 11, 1-12

Abstract: Background: The association between leptin and complement in hepatitis C virus (HCV) infection remains unknown. Methods: A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels. Results: Of the 474 patients, 395 had a sustained virological response (SVR). Pre-therapy leptin levels did not differ between patients with and without an SVR. Univariate and multivariate analyses showed that sex (pre- and post-therapy, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0166712

DOI: 10.1371/journal.pone.0166712

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