The TRIAGE-ProADM Score for an Early Risk Stratification of Medical Patients in the Emergency Department - Development Based on a Multi-National, Prospective, Observational Study

Alexander Kutz, Pierre Hausfater, Devendra Amin, Adina Amin, Pauline Canavaggio, Gabrielle Sauvin, Maguy Bernard, Antoinette Conca, Sebastian Haubitz, Tristan Struja, Andreas Huber, Beat Mueller, Philipp Schuetz and for the TRIAGE study Group

PLOS ONE, 2016, vol. 11, issue 12, 1-17

Abstract: Introduction: The inflammatory biomarker pro-adrenomedullin (ProADM) provides additional prognostic information for the risk stratification of general medical emergency department (ED) patients. The aim of this analysis was to develop a triage algorithm for improved prognostication and later use in an interventional trial. Methods: We used data from the multi-national, prospective, observational TRIAGE trial including consecutive medical ED patients from Switzerland, France and the United States. We investigated triage effects when adding ProADM at two established cut-offs to a five-level ED triage score with respect to adverse clinical outcome. Results: Mortality in the 6586 ED patients showed a step-wise, 25-fold increase from 0.6% to 4.5% and 15.4%, respectively, at the two ProADM cut-offs (≤0.75nmol/L, >0.75–1.5nmol/L, >1.5nmol/L, p ANOVA

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0168076

DOI: 10.1371/journal.pone.0168076

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