Use of ECG and Other Simple Non-Invasive Tools to Assess Pulmonary Hypertension

Gabor Kovacs, Alexander Avian, Vasile Foris, Maria Tscherner, Xhylsime Kqiku, Philipp Douschan, Gerhard Bachmaier, Andrea Olschewski, Marco Matucci-Cerinic and Horst Olschewski

PLOS ONE, 2016, vol. 11, issue 12, 1-12

Abstract: Background: There is a broad consensus that pulmonary hypertension (PH) is to be diagnosed by right heart catheterization (RHC) and that the most important non-invasive tool is echocardiography. However, the role of simple non-invasive tools in the work-up of PH is not clearly defined. We hypothesized that the use of simple non-invasive techniques may help to guide important decisions in the diagnostics of pulmonary hypertension. Objectives: We aimed to develop an algorithm with the use of simple, non-invasive tools in order to identify patients with very high or very low likelihood of PH. Methods: We retrospectively analyzed all consecutive patients undergoing RHC between 2005 and 2010 in our center and performed logistic regression of simple non-invasive parameters regarding detection and exclusion of PH and derived a two-step algorithm. In a prospective study we evaluated this algorithm between 2011 and 2013. Results: The retrospective cohort consisted of n = 394 patients of which 49% presented with PH. Right axis deviation in the ECG was present in 90/394 patients and had a positive predictive value (PPV) of 93% for PH. The combination of non-right axis deviation, N-terminal pro brain natriuretic peptide (NT-proBNP)

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0168706

DOI: 10.1371/journal.pone.0168706

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