Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer

Il Yong Chung, Jong Won Lee, Ji Sung Lee, Yu Rang Park, Yul Ha Min, Yura Lee, Tae In Yoon, Guiyun Sohn, Sae Byul Lee, Jisun Kim, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son and Sei Hyun Ahn

PLOS ONE, 2017, vol. 12, issue 3, 1-11

Abstract: The aim of this study was to determine the relationship between the body mass index (BMI) at a breast cancer diagnosis and various factors including the hormone-receptor, menopause, and lymph-node status, and identify if there is a specific patient subgroup for which the BMI has an effect on the breast cancer prognosis. We retrospectively analyzed the data of 8,742 patients with non-metastatic invasive breast cancer from the research database of Asan Medical Center. The overall survival (OS) and breast-cancer-specific survival (BCSS) outcomes were compared among BMI groups using the Kaplan-Meier method and Cox proportional-hazards regression models with an interaction term. There was a significant interaction between BMI and hormone-receptor status for the OS (P = 0.029), and BCSS (P = 0.013) in lymph-node-positive breast cancers. Obesity in hormone-receptor-positive breast cancer showed a poorer OS (adjusted hazard ratio [HR] = 1.51, 95% confidence interval [CI] = 0.92 to 2.48) and significantly poorer BCSS (HR = 1.80, 95% CI = 1.08 to 2.99). In contrast, a high BMI in hormone-receptor-negative breast cancer revealed a better OS (HR = 0.44, 95% CI = 0.16 to 1.19) and BCSS (HR = 0.53, 95% CI = 0.19 to 1.44). Being underweight (BMI

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0170311

DOI: 10.1371/journal.pone.0170311

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