Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

Max Winerdal, Vijay Urmaliya, Malin E Winerdal, Bertil B Fredholm, Ola Winqvist and Ulrika Ådén

PLOS ONE, 2017, vol. 12, issue 1, 1-7

Abstract: In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0170545

DOI: 10.1371/journal.pone.0170545

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