Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study

Shenghong Li, Ping Li, Honghan Gong, Fei Jiang, Dan Liu, Fengqin Cai, Chonggang Pei, Fuqing Zhou and Xianjun Zeng

PLOS ONE, 2017, vol. 12, issue 1, 1-16

Abstract: Purpose: To investigate the altered intrinsic functional connectivity (iFC) of the primary visual cortex (V1) in primary angle-closure glaucoma (PACG) patients before and after surgery using resting-state functional MRI. Materials and Methods: Twenty-five preoperative PACG (pre-PACG) patients and 25 well-matched healthy controls (HCs) were included in this study, and 9 PACG patients were assessed again at least 3 months after treatment (post-PACG). We generated the iFC maps of the seed regions in the centers of the left and right V1 and conducted group comparisons. Then, the relationships between the altered iFC coefficients and clinical variables were investigated in the pre-PACG patients. Results: Compared with the HCs, the pre-PACG patients showed decreased iFC between the left V1 and right V2 (covering the cuneus, calcarine and lingual gyrus) and increased iFC between the left V1 and left temporal-parietal region, left frontal opercula-insula-basal ganglia region, right insula-basal ganglia region, and right inferior parietal lobule (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0170598

DOI: 10.1371/journal.pone.0170598

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