Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

Gaksch, Martin; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E; Tomaschitz, Andreas; Grübler, Martin; Eiriksdottir, Gudny; Gudmundsson, Elias F; Harris, Tamara B; Cotch, Mary F; Aspelund, Thor; Gudnason, Vilmundur; Rutters, Femke; Beulens, Joline W J; van ‘t Riet, Esther; Nijpels, Giel; Dekker, Jacqueline M; Grove-Laugesen, Diana; Rejnmark, Lars; Busch, Markus A; Mensink, Gert B M; Scheidt-Nave, Christa; Thamm, Michael; Swart, Karin M A; Brouwer, Ingeborg A; Lips, Paul; van Schoor, Natasja M; Sempos, Christopher T; Durazo-Arvizu, Ramón A; Škrabáková, Zuzana; Dowling, Kirsten G; Cashman, Kevin D; Kiely, Mairead; Pilz, Stefan

Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

Martin Gaksch, Rolf Jorde, Guri Grimnes, Ragnar Joakimsen, Henrik Schirmer, Tom Wilsgaard, Ellisiv B Mathiesen, Inger Njølstad, Maja-Lisa Løchen, Winfried März, Marcus E Kleber, Andreas Tomaschitz, Martin Grübler, Gudny Eiriksdottir, Elias F Gudmundsson, Tamara B Harris, Mary F Cotch, Thor Aspelund, Vilmundur Gudnason, Femke Rutters, Joline W J Beulens, Esther van ‘t Riet, Giel Nijpels, Jacqueline M Dekker, Diana Grove-Laugesen, Lars Rejnmark, Markus A Busch, Gert B M Mensink, Christa Scheidt-Nave, Michael Thamm, Karin M A Swart, Ingeborg A Brouwer, Paul Lips, Natasja M van Schoor, Christopher T Sempos, Ramón A Durazo-Arvizu, Zuzana Škrabáková, Kirsten G Dowling, Kevin D Cashman, Mairead Kiely and Stefan Pilz

PLOS ONE, 2017, vol. 12, issue 2, 1-15

Abstract: Background: Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality. Methods: In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OH)D with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488. Findings: We analysed 26916 study participants (median age 61.6 years, 58% females) with a median 25(OH)D concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OH)D concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval) for mortality in the 25(OH)D groups with 40 to 49.99, 30 to 39.99, and

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0170791

DOI: 10.1371/journal.pone.0170791

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