Impact of diabetes mellitus on clinical outcomes of pancreatic cancer after surgical resection: A systematic review and meta-analysis

Xinghua Lv, Wenhui Qiao, Yufang Leng, Lupeng Wu and Yanming Zhou

PLOS ONE, 2017, vol. 12, issue 2, 1-10

Abstract: Background and objective: Diabetes mellitus (DM) is a risk factor for pancreatic cancer but its impact on postoperative outcomes and long-term survival after cancer resection remains controversial. A meta-analysis of published studies was conducted to address this issue. Methods: An extensive electronic search of four databases was performed for relevant articles. Data were processed for meta-analysis using Review Manager version 5.1. Results: Seventeen observational studies involving 5407 patients were subjected to the analysis. Overall morbidity or any type of complications and mortality were comparable between diabetic and non-diabetic subjects. Overall DM has a significant negative impact on survival (risk ratio [RR], 1.24, 95% confidence interval [CI], 1.05–1.45; P = 0.01). Stratification by the type of DM revealed that new-onset DM (

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0171370

DOI: 10.1371/journal.pone.0171370

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