Identifying radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer survivors

Gunnar Steineck, Viktor Skokic, Fei Sjöberg, Cecilia Bull, Eleftheria Alevronta, Gail Dunberger, Karin Bergmark, Ulrica Wilderäng, Jung Hun Oh, Joseph O Deasy and Rebecka Jörnsten

PLOS ONE, 2017, vol. 12, issue 2, 1-15

Abstract: Background: During radiotherapy unwanted radiation to normal tissue surrounding the tumor triggers survivorship diseases; we lack a nosology for radiation-induced survivorship diseases that decrease bowel health and we do not know which symptoms are related to which diseases. Methods: Gynecological-cancer survivors were followed-up two to 15 years after having undergone radiotherapy; they reported in a postal questionnaire the frequency of 28 different symptoms related to bowel health. Population-based controls gave the same information. With a modified factor analysis, we determined the optimal number of factors, factor loadings for each symptom, factor-specific factor-loading cutoffs and factor scores. Results: Altogether data from 623 survivors and 344 population-based controls were analyzed. Six factors best explain the correlation structure of the symptoms; for five of these a statistically significant difference (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0171461

DOI: 10.1371/journal.pone.0171461

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