Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium

Vonk, J M; Scholtens, S; Postma, D S; Moffatt, M F; Jarvis, D; Ramasamy, A; Wjst, M; Omenaas, E R; Bouzigon, E; Demenais, F; Nadif, R; Siroux, V; Polonikov, A V; Solodilova, M; Ivanov, V P; Curjuric, I; Imboden, M; Kumar, A; Probst-Hensch, N; Ogorodova, L M; Puzyrev, V P; Bragina, E Yu; Freidin, M B; Nolte, I M; Farrall, A M; Cookson, W O C M; Strachan, D P; Koppelman, G H; Boezen, H M

Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium

J M Vonk, S Scholtens, D S Postma, M F Moffatt, D Jarvis, A Ramasamy, M Wjst, E R Omenaas, E Bouzigon, F Demenais, R Nadif, V Siroux, A V Polonikov, M Solodilova, V P Ivanov, I Curjuric, M Imboden, A Kumar, N Probst-Hensch, L M Ogorodova, V P Puzyrev, E Yu Bragina, M B Freidin, I M Nolte, A M Farrall, W O C M Cookson, D P Strachan, G H Koppelman and H M Boezen

PLOS ONE, 2017, vol. 12, issue 3, 1-16

Abstract: Background: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma. Methods: We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects. Results: First approach: 50 SNPs were selected based on an overall interaction effect at p

Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172716 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 72716&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0172716

DOI: 10.1371/journal.pone.0172716

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().