IVGTT-based simple assessment of glucose tolerance in the Zucker fatty rat: Validation against minimal models

Micaela Morettini, Emanuela Faelli, Luisa Perasso, Sandro Fioretti, Laura Burattini, Piero Ruggeri and Francesco Di Nardo

PLOS ONE, 2017, vol. 12, issue 3, 1-17

Abstract: For the assessment of glucose tolerance from IVGTT data in Zucker rat, minimal model methodology is reliable but time- and money-consuming. This study aimed to validate for the first time in Zucker rat, simple surrogate indexes of insulin sensitivity and secretion against the glucose-minimal-model insulin sensitivity index (SI) and against first- (Φ1) and second-phase (Φ2) β-cell responsiveness indexes provided by C-peptide minimal model. Validation of the surrogate insulin sensitivity index (ISI) and of two sets of coupled insulin-based indexes for insulin secretion, differing from the cut-off point between phases (FPIR3-SPIR3, t = 3 min and FPIR5-SPIR5, t = 5 min), was carried out in a population of ten Zucker fatty rats (ZFR) and ten Zucker lean rats (ZLR). Considering the whole rat population (ZLR+ZFR), ISI showed a significant strong correlation with SI (Spearman’s correlation coefficient, r = 0.88; P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0173200

DOI: 10.1371/journal.pone.0173200

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