Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity

Pamela S Hair, Laura A Sass, Turaj Vazifedan, Tushar A Shah, Neel K Krishna and Kenji M Cunnion

PLOS ONE, 2017, vol. 12, issue 3, 1-13

Abstract: In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important roles. We have previously shown in a small pilot study that CF sputum soluble fraction concentrations of C5a and C3a were associated with clinical measures of CF disease. Here we report a much larger study of 34 CF subjects providing 169 testable sputum samples allowing longitudinal evaluation comparing C5a and C3a with clinical markers. Levels of the strongly pro-inflammatory C5a correlated negatively with FEV1% predicted (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0173257

DOI: 10.1371/journal.pone.0173257

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