Two studies in one: A propensity-score-matched comparison of fingolimod versus interferons and glatiramer acetate using real-world data from the independent German studies, PANGAEA and PEARL

Jonathan Alsop, Jennie Medin, Christian Cornelissen, Stefan Viktor Vormfelde and Tjalf Ziemssen

PLOS ONE, 2017, vol. 12, issue 5, 1-15

Abstract: Background: This study compared outcomes following fingolimod or BRACE treatments (beta-interferons/glatiramer acetate) in patients with active MS (≥ 1 relapse in the previous year) following previous BRACE treatment. Methods and findings: Patients with active MS who previously received BRACE were identified from German prospective, observational studies, PANGAEA and PEARL. A novel methodology was developed to compare outcomes between propensity-score-matched cohorts (3:1 ratio) from the independent single-arm studies. Patients in PANGAEA (n = 1287) experienced 48% fewer relapses per year than those in PEARL (n = 429; annualized relapse rate ratio: 0.52; p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0173353

DOI: 10.1371/journal.pone.0173353

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