Increased risk of essential tremor in migraine: A population-based retrospective cohort study

Chi-Ieong Lau, Che-Chen Lin, Hsuan-Ju Chen, Han-Cheng Wang, Wei-Hung Chen and Ji-An Liang

PLOS ONE, 2017, vol. 12, issue 3, 1-12

Abstract: Purpose: To examine the long-term risk of essential tremor (ET) in migraine. Methods: Using population-based administrative data from a subset of the National Health Insurance Research Database (NHIRD) of Taiwan, we identified 22,696 newly diagnosed migraineurs (mean age 44.5 years) and a matched migraine-free cohort of 90,784 individuals in the period 2000–2008. Multivariable Cox proportional hazards regression analysis was conducted for assessing the ET risk for the migraine cohort compared to the migraine-free cohort. Results: After adjusting for covariates, the migraine cohort had a 1.83-fold increased risk (95% CI 1.50–2.23) of subsequent ET in comparison to the migraine-free cohort (8.97 vs. 4.81 per 10,000 person-years). In the subgroup analysis, patients with migraine were associated with higher risks of ET, regardless of gender, age or the existence of comorbidities. Conclusion: Our findings demonstrated an association between migraine and ET, suggesting a possible shared pathophysiology underpinning both disorders.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0173586

DOI: 10.1371/journal.pone.0173586

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