Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy

Atsushi Takahashi, Soichi Kono, Akira Wada, Sachie Oshima, Kazumichi Abe, Hiromichi Imaizumi, Masashi Fujita, Manabu Hayashi, Ken Okai, Itaru Miura, Hirooki Yabe and Hiromasa Ohira

PLOS ONE, 2017, vol. 12, issue 4, 1-10

Abstract: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired health-related quality of life including physical and mental state. Near-infrared spectroscopy (NIRS) is a useful tool for evaluation of brain activity and depressive state. This study aimed to determine the brain activity of female NAFLD patients using NIRS. Cerebral oxygenated hemoglobin (oxy-Hb) concentration during a verbal fluency task (VFT) was measured using NIRS in 24 female NAFLD patients and 15 female healthy controls. The Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire was administered to both groups before NIRS. There was no significant difference in CES-D score between groups. However, the oxy-Hb concentration and number of words during the VFT were less in NAFLD compared to healthy controls. The mean value of oxy-Hb concentration during 0–60 s VFT in the frontal lobe was also smaller in NAFLD patients compared to healthy controls (0.082 ± 0.126 vs. 0.183 ± 0.145, P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0174169

DOI: 10.1371/journal.pone.0174169

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