Prognostic impact of diabetes mellitus on hepatocellular carcinoma: Special emphasis from the BCLC perspective

Yu-Wen Su, Po-Hong Liu, Chia-Yang Hsu, Yun-Hsuan Lee, Cheng-Yuan Hsia, Shu-Yein Ho, Ming-Chih Hou, Harn-Shen Chen and Teh-Ia Huo

PLOS ONE, 2017, vol. 12, issue 3, 1-12

Abstract: Background: Diabetes mellitus (DM) is associated with higher incidence and poorer prognosis of hepatocellular carcinoma (HCC). The influence of DM on patient survival in different HCC stages is not known. Methods: A prospective dataset of 3,182 HCC patients was collected between 2002 and 2014. Patients were divided into three groups according to BCLC stages (BCLC stage 0 and stage A, BCLC stage B, BCLC stage C and stage D). We compared the cumulative survival rate of diabetic and non-diabetic patients in different BCLC groups. The correlation between DM and overall survival was also analyzed by multivariate Cox regression model within each group. Results: DM is present in 25.2% of all patients. Diabetic patients had lower cumulative survival in BCLC stage 0 plus BCLC stage A group (log rank p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0174333

DOI: 10.1371/journal.pone.0174333

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