The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

Yong-chao Qiao, Yin-ling Chen, Yan-hong Pan, Fang Tian, Yan Xu, Xiao-xi Zhang and Hai-lu Zhao

PLOS ONE, 2017, vol. 12, issue 4, 1-14

Abstract: Objective: The aim of this study was used meta-analysis to investigate changes of serum tumor necrosis factor-alpha (TNF-α) in patients with type 1 diabetes mellitus (T1DM). Methods: Relevant literatures were identified from PubMed, Cochrane Library, CNKI, WanFang and Chinese-Cqvip databases (published from January 1, 1999 to September 30, 2016). Eligible reports were included for pooled analysis of serum TNF-α level and subgroup analysis was performed in relation with age, disease duration and ethnicity. Results: A total of 23 articles (1631 T1DM cases, 1429 healthy controls) were included for this meta-analysis. Compared with the controls, the patients had significantly increased serum TNF-α level (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0176157

DOI: 10.1371/journal.pone.0176157

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