Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis

Guo-dong Cao, Bo Chen and Mao-ming Xiong

PLOS ONE, 2017, vol. 12, issue 6, 1-16

Abstract: Objectives: Metastasis-associated protein 1 (MTA1) is a transcriptional regulator and significantly associated with prognosis of patients with cancer. However, its role as a potential prognostic marker in digestive tract cancer (DTC) is controversial. In this study, a meta-analysis was conducted to evaluate the MTA1 expression as a predictor of clinicopathology and survival of patients with DTC. Methods: We searched PubMed, Ovid, Web of Science and Cochrane databases using multiple search strategies for eligible studies. STATA 11.0 software was used to pool the data and analyze the association, odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the strength of the association. Furthermore, the Newcastle-Ottawa scale was used to evaluate the quality of eligible studies. Results: MTA1 overexpression was strongly associated with depth of invasion (OR = 1.88, 95%CI: 1.05–3.37, P = 0.03), lymph node metastasis (OR = 2.30, 95%CI: 1.76–3.01, P

Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176431 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 76431&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0176431

DOI: 10.1371/journal.pone.0176431

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().