Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Yinyin Wu, Juntao Ni, Xiao Cai, Fuzhi Lian, Haiyan Ma, Liangwen Xu and Lei Yang

PLOS ONE, 2017, vol. 12, issue 5, 1-16

Abstract: Background and objective: Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility. Methods: One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models. Results: Significant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0177023

DOI: 10.1371/journal.pone.0177023

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