Emergence of CXCR4-tropic HIV-1 variants followed by rapid disease progression in hemophiliac slow progressors

Tsunefusa Hayashida, Kiyoto Tsuchiya, Yoshimi Kikuchi, Shinichi Oka and Hiroyuki Gatanaga

PLOS ONE, 2017, vol. 12, issue 5, 1-13

Abstract: Objective: The association between emergence of CXCR4-tropic HIV-1 variants (X4 variants) and disease progression of HIV-1 infection has been reported. However, it is not known whether the emergence of X4 variants is the cause or result of HIV-1 disease progression. We tried to answer this question. Design: HIV-1 env sequences around the V3 region were analyzed in serially stocked samples in order to determine whether X4 variants emerged before or after the fall in CD4+ T-cell count. Methods: The study subjects were five HIV-1-infected hemophiliac slow progressors. Deep sequencing around the HIV-1 env V3 region was conducted in duplicate. Tropism was predicted by geno2pheno [coreceptor] 2.5 with cutoff value of false positive ratio at

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0177033

DOI: 10.1371/journal.pone.0177033

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