Preoperative serum cystatin-C as a potential biomarker for prognosis of renal cell carcinoma

Shengjie Guo, Yunfei Xue, Qiuming He, Xiaobo He, Kunbin Guo, Pei Dong, Kai Yao, Guangwei Yang, Dong Chen, Zaishang Li, Xiangdong Li, Zike Qin, Zhuowei Liu, Wenjie Cheng, Chao Guo, Meng Zhang, Hui Han and Fangjian Zhou

PLOS ONE, 2017, vol. 12, issue 6, 1-18

Abstract: Purpose: The prognostic value of serum cystatin-C (Cys-C) in renal cell carcinoma (RCC) remains unknown. The purpose of this study is to explore the prognostic value of Cys-C for RCC patients. Patients and methods: The levels of preoperative Cys-C, creatinine (CRE) and estimated glomerular filtration rate (e-GFR) were retrospectively collected in 325 RCC patients undergoing surgery. The cutoff values of Cys-C, CRE and e-GFR were determined by the standardized Cutoff Finder algorithm. The receiver operating characteristic (ROC) curve and pairwise comparison were performed to compare the three variables. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum Cys-C in RCC. Results: Based on the analysis of Cutoff Finder algorithm, ROC curve and pairwise comparison, the preoperative Cys-C was superior to CRE and e-GFR as a predictive factor in RCC. Multivariate Cox regression analyses showed that high preoperative Cys-C (>1.09 mg/L) was significantly associated with shorter overall survival (OS) in all RCC patients (hazard ratio [HR], 1.59; P = 0.012), patients at pT1-2 (P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0178823

DOI: 10.1371/journal.pone.0178823

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