Improvement of atropine on esophagogastric junction observation during sedative esophagogastroduodenoscopy

Zhihao Chen, Lingang Liu, Jiangfeng Tu, Guangming Qin, Weiwei Su, Xiaoge Geng, Xiaojun Chen, Hongguang Wu and Wensheng Pan

PLOS ONE, 2017, vol. 12, issue 6, 1-10

Abstract: Background and study aims: Although sedation esophagogastroduodenoscopy (EGD) is now widely used, previous research has reported that sedation during EGD exhibits a negative effect on esophagogastric junction (EGJ) exposure. Atropine might improve EGJ exposure, as noted in clinical practice. The aim of this study was to examine whether sedation had a negative effect on EGJ observation in the Chinese population, and whether atropine had some ability to act as an antidote to this unexpected secondary effect of sedation. Patients and methods: In this cross-sectional study, subjects were divided into the following three groups according to the methods of EGD examination: the non-sedation group, the propofol-fentanyl combined sedation group and the combined sedation with atropine administration group. The EGJ observation was assessed by a key photograph taken with the endoscopic camera 1 cm from the EGJ, which was rated on the following four-degree scale: excellent (score = 4), good (score = 3), fair (score = 2) and poor (score = 1). Results: The EGJ exposure was better in the sedation group administered atropine (score = 2.64±1.05) than in the sedation group (score = 1.99±1.08, P

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0179490

DOI: 10.1371/journal.pone.0179490

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