Heart rate variability as predictor of mortality in sepsis: A prospective cohort study

Fábio M de Castilho, Antonio Luiz P Ribeiro, José Luiz P da Silva, Vandack Nobre and Marcos R de Sousa

PLOS ONE, 2017, vol. 12, issue 6, 1-15

Abstract: Background: Sepsis is a serious medical condition with increasing prevalence and high mortality. The role of the autonomic nervous system in pathophysiology of sepsis has been increasingly researched. The objective of this study is to evaluate the Heart rate variability (HRV) as a predictor of mortality in septic patients. Methods: This was a prospective cohort of patients diagnosed with sepsis. Patient recruitment was carried out at ICU in tertiary university hospital between March 2012 and February 2014. Clinical data and laboratory exams were collected at admission. Each patient underwent a 20-minute Holter and a 24-hour Holter on the first day of enrollment. The primary outcome was the 28-day all-cause mortality. Results: A total of 63 patients were included. Patients were categorized into nonsurvivor group (n = 16) or survivor group (n = 47) depending on this endpoint. Survivors were younger (48.6 years vs. 63.0 years), had better renal function and lower values in severity scores (APACHE II and SOFA) compared to nonsurvivors. In the 20-minute Holter, SDNN, Total Power, VLF Power, LF Power and LF/HF of nonsurvivors were significantly lower than those of survivors (p =

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0180060

DOI: 10.1371/journal.pone.0180060

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