Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults

John Bellettiere, Elisabeth A H Winkler, Sebastien F M Chastin, Jacqueline Kerr, Neville Owen, David W Dunstan and Genevieve N Healy

PLOS ONE, 2017, vol. 12, issue 6, 1-17

Abstract: Background: High amounts of time spent sitting can increase cardiovascular disease risk and are deleteriously associated cardio-metabolic risk biomarkers. Though evidence suggests that accruing sitting time in prolonged periods may convey additional risk, verification using high-quality measures is needed. We examined this issue in adults from the Australian Diabetes, Obesity and Lifestyle Study, using accurate measures of sitting accumulation. Methods: In 2011/12, 739 adults aged 36 to 89 years (mean±SD 58±10 years) wore activPAL3™ monitors (which provide accurate objective measures of sitting); 678 provided ≥4 valid days of monitor data and complete cardio-metabolic biomarker and confounder data. Multivariable linear regression models examined associations of sitting time, sitting time accrued in ≥30 minute bouts (prolonged sitting time), and three measures of sitting accumulation patterns with cardio-metabolic risk markers: body mass index (BMI), waist circumference, blood pressure, high- and low- density lipoprotein (HDL and LDL) cholesterol, triglycerides, glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 2-hour post-load glucose (PLG). Interactions tests examined whether associations of sitting time with biomarkers varied by usual sitting bout duration. Results: Adjusted for potential confounders, greater amounts of sitting time and prolonged sitting time were significantly (p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0180119

DOI: 10.1371/journal.pone.0180119

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