The prognostic and clinicopathologic characteristics of CD147 and esophagus cancer: A meta-analysis

Hui Li, Chunxiang Jiang, Dongwen Wu, Shupeng Shi, Mengting Liao, Jing Wang, Yanwen Li and Zihao Xu

PLOS ONE, 2017, vol. 12, issue 7, 1-15

Abstract: Objective: The prognostic significance of CD147 expression in esophageal cancer patients remains controversial. Using a meta-analysis, we investigated the prognostic and clinicopathologic characteristics of CD147 in esophageal cancer. Methods: A comprehensive literature search of the PubMed (1966–2016), EMBASE (1980–2016), Cochrane Library (1996–2016), Web of Science (1945–2016), China National Knowledge Infrastructure (1982–2016), and Wanfang databases (1988–2016) was performed to identify studies of all esophageal cancer subtypes. Correlations between CD147 expression and survival outcomes and clinicopathological features were analyzed using meta-analysis methods. Results: Seventeen studies were included. High CD147 expression reduced the 3-year survival rate (OR = 3.26, 95% CI = (1.53, 6.93), p = 0.02) and 5-year survival rate(OR = 4.35, 95% CI = (2.13, 8.90), p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0180271

DOI: 10.1371/journal.pone.0180271

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